Ontology highlight
ABSTRACT:
SUBMITTER: Zhou T
PROVIDER: S-EPMC5992566 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Zhou Tian T Lin Zhiyi Z Puligujja Pavan P Palandri Diana D Hilaire James J Araínga Mariluz M Smith Nathan N Gautam Nagsen N McMillan JoEllyn J Alnouti Yazen Y Liu Xinming X Edagwa Benson B Gendelman Howard E HE
Nanomedicine (London, England) 20180319 8
<h4>Aim</h4>While the therapeutic potential for current long-acting (LA) antiretroviral therapy (ART) is undeniable, ligand-decorated nanoformulated LA-ART could optimize drug delivery to viral reservoirs. The development of decorated ART hinges, however, on formulation processes and manufacture efficiencies. To this end, we compared manufacture and purification techniques for ligand-decorated antiretroviral drug nanocrystals.<h4>Materials & methods</h4>Ligand-decorated nanoparticle manufacturi ...[more]