Ontology highlight
ABSTRACT:
SUBMITTER: Platani M
PROVIDER: S-EPMC5992584 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Journal of cell science 20180501 9
In metazoa, the Nup107 complex (also known as the nucleoporin Y-complex) plays a major role in formation of the nuclear pore complex in interphase and is localised to kinetochores in mitosis. The Nup107 complex shares a single highly conserved subunit, Seh1 (also known as SEH1L in mammals) with the GATOR2 complex, an essential activator of mTORC1 kinase. mTORC1/GATOR2 has a central role in the coordination of cell growth and proliferation. Here, we use chemical genetics and quantitative chromoso ...[more]