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Albumin mass balance and kinetics in liver transplantation.

ABSTRACT: BACKGROUND:In major abdominal surgery albumin is shifted from the circulation, presumably leaking into the interstitial space, contributing to a 30-40% decrease in plasma albumin concentration. During and after liver transplantation exogenous albumin is infused for volume substitution and to maintain plasma albumin concentration. Here we used liver transplantation as a model procedure for the study of albumin mass balance and kinetics during major abdominal surgery with albumin substitution. METHODS:Patients were studied during liver transplantation (n?=?16), and until postoperative day 3 (POD 3) (n?=?11). Cumulative perioperative albumin shift was assessed by mass balance of albumin and hemoglobin. Synthesis rates of albumin and fibrinogen were estimated by the flooding technique using deuterium-labeled phenylalanine. Albumin distribution was assessed by radioiodinated human serum albumin. RESULTS:At the end of surgery, 37?±?17 g of albumin (p?

SUBMITTER: Amouzandeh M

PROVIDER: S-EPMC5992699 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Albumin mass balance and kinetics in liver transplantation.

Amouzandeh Mariam M Nowak Greg G Januszkiewicz Anna A Wernerman Jan J Rooyackers Olav O Norberg Åke Å

Critical care (London, England) 20180607 1

<h4>Background</h4>In major abdominal surgery albumin is shifted from the circulation, presumably leaking into the interstitial space, contributing to a 30-40% decrease in plasma albumin concentration. During and after liver transplantation exogenous albumin is infused for volume substitution and to maintain plasma albumin concentration. Here we used liver transplantation as a model procedure for the study of albumin mass balance and kinetics during major abdominal surgery with albumin substitut ...[more]

PMID: 29880012

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