Ontology highlight
ABSTRACT:
SUBMITTER: Kong WJ
PROVIDER: S-EPMC5993056 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Kong Wei-Jun WJ Chen Xingrong X Wang Mingming M Dai Hui-Xiong HX Yu Jin-Quan JQ
Organic letters 20171219 1
Here we report an aerobic Pd(0) catalyzed C2-H functionalization of indoles and pyrroles with tethered N-methoxylamide as the directing group. A Pd(0)-initiated mechanism overcomes the directing or poisoning effect from a wide range of heterocycles including pyridine, pyrimidine, and thiazole. The imidazo[1,5-a]indole products are transformed to bioactive analogs after one-step manipulations, demonstrating the potential utility of this reaction in drug discovery. ...[more]