Ontology highlight
ABSTRACT:
SUBMITTER: Levings DC
PROVIDER: S-EPMC5993100 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Levings Daniel C DC Nakato Hiroshi H
Glycobiology 20181201 1
The stem cell niche normally prevents aberrant stem cell behaviors that lead to cancer formation. Recent studies suggest that some cancers are derived from endogenous populations of adult stem cells that have somehow escaped from normal control by the niche. However, the molecular mechanisms by which the niche retains stem cells locally and tightly controls their divisions are poorly understood. Here, we demonstrate that the presence of heparan sulfate (HS), a class glygosaminoglycan chains, in ...[more]