Ontology highlight
ABSTRACT:
SUBMITTER: Cheng C
PROVIDER: S-EPMC5993136 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cheng Chunming C Geng Feng F Cheng Xiang X Guo Deliang D
Cancer communications (London, England) 20180521 1
Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy. Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. Lipids constitute the basic structure of membranes and also function as signaling molecules and energy sources. Sterol regulatory element-binding proteins (SREBPs), a family of membrane-bound transcription factors in the endoplasmic reticulum, play a central role in the regulation of lipid metabolism. R ...[more]