Ontology highlight
ABSTRACT:
SUBMITTER: Odermatt DC
PROVIDER: S-EPMC5993189 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Odermatt Diana C DC Gari Kerstin K
Cell reports 20170201 6
The cytoplasmic iron-sulfur assembly (CIA) targeting complex is required for the transfer of an iron-sulfur (Fe-S) cluster to cytoplasmic and nuclear proteins, but how it engages with client proteins is unknown. Here, we show that the complex members MIP18 and CIAO1 associate with the C terminus of MMS19. By doing so, they form a docking site for Fe-S proteins that is disrupted in the absence of either MMS19 or MIP18. The Fe-S helicase XPD seems to be the only exception, since it can interact wi ...[more]