Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration.
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ABSTRACT:
SUBMITTER: Goverdhan SV
PROVIDER: S-EPMC5993190 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Publications
Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration.
Goverdhan S V SV Ennis S S Hannan S R SR Madhusudhana K C KC Cree A J AJ Luff A J AJ Lotery A J AJ
The British journal of ophthalmology 20080229 4
<h4>Background/aims</h4>To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD).<h4>Methods</h4>DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL1beta -511C/T, IL6 -174C/G, IL8 -251A/T and anti-inflammatory IL10 -1082G/A cytokine polymorphisms using the 5' nuclease TaqMan(R) assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies.<h4>Results</ ...[more]
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