Longitudinal accrual of neocortical amyloid burden is associated with microstructural changes of the fornix in cognitively normal adults.
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ABSTRACT:
SUBMITTER: Song Z
PROVIDER: S-EPMC5993596 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
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Longitudinal accrual of neocortical amyloid burden is associated with microstructural changes of the fornix in cognitively normal adults.
Song Zhuang Z Farrell Michelle E ME Chen Xi X Park Denise C DC
Neurobiology of aging 20180306
The fornix and parahippocampal cingulum are 2 major limbic tracts in the core memory network of the hippocampus. Although these fiber tracts are known to degrade with Alzheimer's disease (AD), little is known about their vulnerability in the asymptomatic phase of AD. In this longitudinal study of cognitively normal adults, we assessed amyloid-beta (Aβ) plaques using positron emission tomography and white matter microstructure using diffusion tensor imaging. We found that an increase of neocortic ...[more]
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