Ontology highlight
ABSTRACT:
SUBMITTER: Kim JH
PROVIDER: S-EPMC5993643 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Kim Ji Hun JH Titus Katelyn R KR Gong Wanfeng W Beagan Jonathan A JA Cao Zhendong Z Phillips-Cremins Jennifer E JE
Methods (San Diego, Calif.) 20180524
Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs, and looping interactions. Currently, there is a great need to evaluate the link between chromatin topology and genome function across many biological conditions and genetic perturbations. Hi-C can generate genome-wide maps of looping interactions but is intractable for high-throughput comparison of loops across multiple conditions due to the enormous number of reads (>6 Billion) requir ...[more]