Ontology highlight
ABSTRACT:
SUBMITTER: Giroux V
PROVIDER: S-EPMC5993649 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Giroux Véronique V Stephan Julien J Chatterji Priya P Rhoades Ben B Wileyto E Paul EP Klein-Szanto Andres J AJ Lengner Christopher J CJ Hamilton Kathryn E KE Rustgi Anil K AK
Stem cell reports 20180524 6
Two principal stem cell pools orchestrate the rapid cell turnover in the intestinal epithelium. Rapidly cycling Lgr5+ stem cells are intercalated between the Paneth cells at the crypt base (CBCs) and injury-resistant reserve stem cells reside above the crypt base. The intermediate filament Keratin 15 (Krt15) marks either stem cells or long-lived progenitor cells that contribute to tissue repair in the hair follicle or the esophageal epithelium. Herein, we demonstrate that Krt15 labels long-lived ...[more]