The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Chen XX
PROVIDER: S-EPMC5994512 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
The impact of <i>GAB2</i> genetic variations on cerebrospinal fluid markers in Alzheimer's disease.
Chen Xiao-Xiao XX Guo Run-Rong RR Cao Xi-Peng XP Tan Lin L Tan Lan L
Annals of translational medicine 20180501 10
<h4>Background</h4>Growth factor receptor-bound protein-associated binding protein 2 gene (<i>GAB2</i>) has been regarded as one of the susceptibility gene associated with Alzheimer's disease (AD). However, the role of <i>GAB2</i> polymorphisms on cerebrospinal fluid (CSF) proteins in AD continuum remains unclear.<h4>Methods</h4>We evaluated the connection between four single nucleotide polymorphisms (SNPs) of <i>GAB2</i> and AD-related CSF biomarkers including amyloid β (Aβ), total tau (T-tau) ...[more]
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