Dataset Information

Association of lectin-like oxidized low density lipoprotein receptor 1 (OLR1) polymorphisms with late-onset Alzheimer disease in Han Chinese.

ABSTRACT: Background:Lectin-like oxidized low density lipoprotein receptor 1 (OLR1) locates within the area of chromosome 12p, which has been identified as the AD-susceptible region, and plays a role in lipid metabolism. Therefore, it has been suggested to be a good candidate gene for Alzheimer's disease (AD). Several SNPs within OLR1 have been reported to have association with AD among Caucasians. Methods:We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese. Results:No significant association was found between the OLR1 (rs1050283, rs1050286, rs17808009) polymorphisms and LOAD, even after adjustment for gender and age and stratification for apolipoprotein E (APOE) status. Conclusions:Our study showed that the SNPs (rs1050283, rs1050286, rs17808009) located in the 3'UTR of OLR1 may not involve in the mechanism of LOAD in Han Chinese population.

SUBMITTER: Wang ZT

PROVIDER: S-EPMC5994529 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Publications

Association of lectin-like oxidized low density lipoprotein receptor 1 (<i>OLR1</i>) polymorphisms with late-onset Alzheimer disease in Han Chinese.

Wang Zuo-Teng ZT Zhong Xiao-Ling XL Tan Meng-Shan MS Wang Hui-Fu HF Tan Chen-Chen CC Zhang Wei W Zheng Zhan-Jie ZJ Kong Ling-Li LL Tan Lan L Sun Li L

Annals of translational medicine 20180501 10

<h4>Background</h4>Lectin-like oxidized low density lipoprotein receptor 1 (OLR1) locates within the area of chromosome 12p, which has been identified as the AD-susceptible region, and plays a role in lipid metabolism. Therefore, it has been suggested to be a good candidate gene for Alzheimer's disease (AD). Several SNPs within OLR1 have been reported to have association with AD among Caucasians.<h4>Methods</h4>We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to in ...[more]

PMID: 29951494

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Project description:In-stent restenosis (ISR) is the most common complication associated with percutaneous coronary intervention (PCI). Although some studies have reported an association between lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and ISR, not enough clinical validation data are available to support this link. Here, we report our cross-sectional study aimed at exploring the feasibility of LOX-1 as a biomarker for the prognostic diagnosis of patients undergoing PCI.Three groups were included: ISR group, including 99 patients with ISR diagnosed with coronary arteriography (CAG) after PCI; lesion group, comprising 87 patients with coronary artery stenosis (<50%) diagnosed with CAG after PCI; and control group, consisting of 96 volunteers with no coronary artery disease. The levels of LOX-1 were measured in each patient by using an enzyme-linked immunosorbent assay, and their general information as well as laboratory parameters were recorded and followed up during a period of 2 years.LOX-1 levels gradually increased after PCI along with the progression of the lesion in the 3 groups. The levels of LOX-1 were significantly higher in the ISR group than in the other 2 groups (P?<?.001). LOX-1 levels were correlated with the levels of uric acid (UA) (r?=?0.289, P?=?.007), creatinine (CREA) (r?=?.316, P?=?.003), and high-density lipoprotein cholesterol (HDL-C) (r?=?-0.271, P?=?.012), whereas no statistically significant correlation was detected with the Gensini score (r?=?0.157, P?=?.141). The sensitivity and specificity of LOX-1 were 81.5% and 55.7%, respectively, with the most optimal threshold (5.04??g/L). The area under curve (AUC) of the receiver operator characteristic (ROC) curve of LOX-1 was 0.720, and LOX-1 had the highest AUC compared with CREA, UA, and HDL-C, both individually and in combination.A high level of LOX-1 in the early period after PCI has a certain predictive power and diagnostic value for ISR. However, the level of LOX-1 is not related to the Gensini score of coronary artery after PCI, and CREA and UA, which are weakly related to LOX-1, have no obvious synergy in the diagnosis of ISR with LOX-1.

Dataset Information

Association of lectin-like oxidized low density lipoprotein receptor 1 (OLR1) polymorphisms with late-onset Alzheimer disease in Han Chinese.

Publications

Association of lectin-like oxidized low density lipoprotein receptor 1 (<i>OLR1</i>) polymorphisms with late-onset Alzheimer disease in Han Chinese.

Similar Datasets

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