AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.
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ABSTRACT:
SUBMITTER: Philippe C
PROVIDER: S-EPMC5994775 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.
Philippe Chloé C Pinson Benoît B Dompierre Jim J Pantesco Véronique V Viollet Benoît B Daignan-Fornier Bertrand B Moenner Michel M
Neoplasia (New York, N.Y.) 20180503 6
AICAR (Acadesine) is a pharmacological precursor of purine nucleotide biosynthesis with anti-tumoral properties. Although recognized as an AMP mimetic activator of the protein kinase AMPK, the AICAR monophosphate derivative ZMP was also shown to mediate AMPK-independent effects. In order to unveil these AMPK-independent functions, we performed a transcriptomic analysis in AMPKα1/α2 double knockout murine embryonic cells. Kinetic analysis of the cellular response to AICAR revealed the up-regulati ...[more]
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