Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity.
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ABSTRACT:
SUBMITTER: Hayward JA
PROVIDER: S-EPMC5995163 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity.
Hayward Joshua A JA Tachedjian Mary M Cui Jie J Cheng Adam Z AZ Johnson Adam A Baker Michelle L ML Harris Reuben S RS Wang Lin-Fa LF Tachedjian Gilda G
Molecular biology and evolution 20180701 7
Bats have attracted attention in recent years as important reservoirs of viruses deadly to humans and other mammals. These infections are typically nonpathogenic in bats raising questions about innate immune differences that might exist between bats and other mammals. The APOBEC3 gene family encodes antiviral DNA cytosine deaminases with important roles in the suppression of diverse viruses and genomic parasites. Here, we characterize pteropid APOBEC3 genes and show that species within the genus ...[more]
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