Simulated Microgravity Impairs Cardiac Autonomic Neurogenesis from Neural Crest Cells.
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ABSTRACT:
SUBMITTER: Hatzistergos KE
PROVIDER: S-EPMC5995268 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Simulated Microgravity Impairs Cardiac Autonomic Neurogenesis from Neural Crest Cells.
Hatzistergos Konstantinos E KE Jiang Zhijie Z Valasaki Krystalenia K Takeuchi Lauro M LM Balkan Wayne W Atluri Preethi P Saur Dieter D Seidler Barbara B Tsinoremas Nicholas N DiFede Darcy L DL Hare Joshua M JM
Stem cells and development 20180320 12
Microgravity-induced alterations in the autonomic nervous system (ANS) contribute to derangements in both the mechanical and electrophysiological function of the cardiovascular system, leading to severe symptoms in humans following space travel. Because the ANS forms embryonically from neural crest (NC) progenitors, we hypothesized that microgravity can impair NC-derived cardiac structures. Accordingly, we conducted in vitro simulated microgravity experiments employing NC genetic lineage tracing ...[more]
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