Ontology highlight
ABSTRACT:
SUBMITTER: Natan E
PROVIDER: S-EPMC5995306 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20180212 3
Cotranslational protein folding can facilitate rapid formation of functional structures. However, it can also cause premature assembly of protein complexes, if two interacting nascent chains are in close proximity. By analyzing known protein structures, we show that homomeric protein contacts are enriched toward the C termini of polypeptide chains across diverse proteomes. We hypothesize that this is the result of evolutionary constraints for folding to occur before assembly. Using high-throughp ...[more]