Ontology highlight
ABSTRACT:
SUBMITTER: Begam M
PROVIDER: S-EPMC5995314 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Begam Morium M Collier Alyssa F AF Mueller Amber L AL Roche Renuka R Galen Sujay S SS Roche Joseph A JA
Physiological reports 20180601 11
B6.A-Dysf<sup>prmd</sup> /GeneJ (BLAJ) mice model human limb-girdle muscular dystrophy 2B (LGMD2B), which is linked to mutations in the dysferlin (DYSF) gene. We tested the hypothesis that, the calcium ion (Ca<sup>2+</sup> ) channel blocker diltiazem (DTZ), reduces contraction-induced skeletal muscle damage, in BLAJ mice. We randomly assigned mice (N = 12; 3-4 month old males) to one of two groups - DTZ (N = 6) or vehicle (VEH, distilled water, N = 6). We conditioned mice with either DTZ or VEH ...[more]