Ontology highlight
ABSTRACT:
SUBMITTER: Feodorova VA
PROVIDER: S-EPMC5995359 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Feodorova Valentina A VA Lyapina Anna M AM Khizhnyakova Maria A MA Zaitsev Sergey S SS Sayapina Lidiya V LV Arseneva Tatiana E TE Trukhachev Alexey L AL Lebedeva Svetlana A SA Telepnev Maxim V MV Ulianova Onega V OV Lyapina Elena P EP Ulyanov Sergey S SS Motin Vladimir L VL
PLoS neglected tropical diseases 20180611 6
<h4>Background</h4>To establish correlates of human immunity to the live plague vaccine (LPV), we analyzed parameters of cellular and antibody response to the plasminogen activator Pla of Y. pestis. This outer membrane protease is an essential virulence factor that is steadily expressed by Y. pestis.<h4>Methodology/principal findings</h4>PBMCs and sera were obtained from a cohort of naïve (n = 17) and LPV-vaccinated (n = 34) donors. Anti-Pla antibodies of different classes and IgG subclasses wer ...[more]