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Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development.

ABSTRACT: BACKGROUND:WNT1-inducible signaling pathway protein 1 (WISP1) is a member of CCN protein family and a downstream target of ?-catenin. Aberrant WISP1 expression is associated with carcinogenesis. In the current study, we focused on examining WISP1 single nucleotide polymorphisms (SNPs) to elucidate hepatocellular carcinoma (HCC) clinicopathologic characteristics. METHODOLOGY/PRINCIPAL FINDINGS:The WISP1 SNPs rs2977530, rs2977537, rs2929973, rs2929970, rs62514004, and rs16893344 were analyzed by real-time polymerase chain reaction in 332 patients with HCC and 664 cancer-free controls. RESULTS:The patients with higher frequencies of WISP1 rs62514004 (AG + GG) and rs16893344 (CT + TT) variants revealed a lower risk to reach a later clinical stage compared with their wild-type carriers. Furthermore, individuals who carried WISP1 rs62514004 and rs16893344 haplotype G-T showed a greater synergistic effect combined with alcohol drinking on HCC development (AOR = 26.590, 95% CI = 9.780-72.295). CONCLUSIONS:Our results demonstrated that the HCC patients with WISP1 SNPs are associated with HCC development, and WISP1 SNPs may serve as markers or therapeutic targets for HCC.

SUBMITTER: Chen CT 

PROVIDER: S-EPMC5995385 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development.

Chen Chih-Tien CT   Lee Hsiang-Lin HL   Chiou Hui-Ling HL   Chou Chia-Hsuan CH   Wang Po-Hui PH   Yang Shun-Fa SF   Chou Ying-Erh YE  

PloS one 20180611 6

<h4>Background</h4>WNT1-inducible signaling pathway protein 1 (WISP1) is a member of CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression is associated with carcinogenesis. In the current study, we focused on examining WISP1 single nucleotide polymorphisms (SNPs) to elucidate hepatocellular carcinoma (HCC) clinicopathologic characteristics.<h4>Methodology/principal findings</h4>The WISP1 SNPs rs2977530, rs2977537, rs2929973, rs2929970, rs62514004, and rs16893344 wer  ...[more]

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