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Observation of Ultrafast Vibrational Energy Transfer in Fibrinogen and Fibrin Fibers.

ABSTRACT: We study the secondary structure of the blood protein fibrinogen using two-dimensional infrared spectroscopy. With this technique, we identify the amide I' vibrational modes of the antiparallel β-sheets and turns of fibrinogen. We observe ultrafast energy flow among these amide I' vibrational modes with a time constant of ∼7 ps. This energy transfer time constant does not change significantly upon fibrin fiber formation, indicating that the secondary structure of the fibrinogen monomers remains largely unchanged in the polymerization process.

SUBMITTER: Dutta B

PROVIDER: S-EPMC5995459 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Observation of Ultrafast Vibrational Energy Transfer in Fibrinogen and Fibrin Fibers.

Dutta Biplab B Vos Bart E BE Rezus Yves L A YLA Koenderink Gijsje H GH Bakker Huib J HJ

The journal of physical chemistry. B 20180525 22

We study the secondary structure of the blood protein fibrinogen using two-dimensional infrared spectroscopy. With this technique, we identify the amide I' vibrational modes of the antiparallel β-sheets and turns of fibrinogen. We observe ultrafast energy flow among these amide I' vibrational modes with a time constant of ∼7 ps. This energy transfer time constant does not change significantly upon fibrin fiber formation, indicating that the secondary structure of the fibrinogen monomers remains ...[more]

PMID: 29709181

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