Ontology highlight
ABSTRACT:
SUBMITTER: Froese DS
PROVIDER: S-EPMC5995969 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Froese D Sean DS Kopec Jolanta J Rembeza Elzbieta E Bezerra Gustavo Arruda GA Oberholzer Anselm Erich AE Suormala Terttu T Lutz Seraina S Chalk Rod R Borkowska Oktawia O Baumgartner Matthias R MR Yue Wyatt W WW
Nature communications 20180611 1
The folate and methionine cycles are crucial for biosynthesis of lipids, nucleotides and proteins, and production of the methyl donor S-adenosylmethionine (SAM). 5,10-methylenetetrahydrofolate reductase (MTHFR) represents a key regulatory connection between these cycles, generating 5-methyltetrahydrofolate for initiation of the methionine cycle, and undergoing allosteric inhibition by its end product SAM. Our 2.5 Å resolution crystal structure of human MTHFR reveals a unique architecture, append ...[more]