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Diagnostic accuracy of diffusion weighted imaging for differentiation of supratentorial pilocytic astrocytoma and pleomorphic xanthoastrocytoma.


ABSTRACT: PURPOSE:Supratentorial pilocytic astrocytoma (PA) may mimic pleomorphic xanthoastrocytoma (PXA) on conventional MR imaging, and a differentiation is clinically important because of distinct recurrence rate and anaplastic transformation rate. The purpose of this study was to investigate the diagnostic potential of diffusion-weighted imaging (DWI) in differentiating supratentorial PA from PXA. METHODS:We retrospectively reviewed DWI and conventional MR imaging of 16 patients with supratentorial PA and 8 patients with PXA. Variables of mean ADC values (ADCmean) and minimum ADC values (ADCmin) were calculated from the ROIs containing the contrast-enhancing lesion on DWI. ADCmean values and ADCmin values were compared among all supratentorial PA and PXA as well as between the subgroup of lobar PA and PXA by using an unpaired Student's t test. The optimum threshold, sensitivity, specificity, accuracy, and the area under the receiver operating characteristic curve (AUC) were determined. RESULTS:Both ADCmean values (1542?±?186 vs 1084?±?201?×?10-6 mm2/s; P??1189.8?×?10-6 mm2/s (sensitivity, 93.8%; specificity, 100%). The optimal threshold values of >?1189.8?×?10-6 mm2/s for ADCmean values provide sensitivity and specificity of 85.7 and 100%, respectively, for discriminating lobar PA from PXA. The optimum threshold value for ADCmin was >?1063.5?×?10-6 mm2/s. CONCLUSION:DWI is helpful in characterization and differentiation of supratentorial PA from PXA.

SUBMITTER: She D 

PROVIDER: S-EPMC5996010 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Diagnostic accuracy of diffusion weighted imaging for differentiation of supratentorial pilocytic astrocytoma and pleomorphic xanthoastrocytoma.

She Dejun D   Liu Jianyi J   Zeng Z Z   Xing Z Z   Cao Dairong D  

Neuroradiology 20180524 7


<h4>Purpose</h4>Supratentorial pilocytic astrocytoma (PA) may mimic pleomorphic xanthoastrocytoma (PXA) on conventional MR imaging, and a differentiation is clinically important because of distinct recurrence rate and anaplastic transformation rate. The purpose of this study was to investigate the diagnostic potential of diffusion-weighted imaging (DWI) in differentiating supratentorial PA from PXA.<h4>Methods</h4>We retrospectively reviewed DWI and conventional MR imaging of 16 patients with su  ...[more]

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