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Data regarding clinical evaluation of collagen membrane in oral mucosal defects due to oral submucous fibrosis and leukoplakia.

ABSTRACT: This data depicts the clinical evaluation of collagen membrane in oral mucosal defects due to oral submucous fibrosis and leukoplakia. This data comprised of 10 patients in the age group of 20-60 (3 male and 2 female patients with grade III and grade IV oral submucous fibrosis and 5 male patients with oral leukoplakia with a size of 3-5?cm in diameter). The parameters such as pain, swelling, allergy, biodegradability of collagen membrane, degree of re-epithelisation, degree of contracture, mouth opening and wound size were assessed after the placement of collagen membrane in oral mucosal defects. There is less data regarding the usage of collagen membrane as a biological dressing material to cover mucosal defects (Rastogi et al., 2009) [1].

SUBMITTER: Jasthi VC

PROVIDER: S-EPMC5996286 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Data regarding clinical evaluation of collagen membrane in oral mucosal defects due to oral submucous fibrosis and leukoplakia.

Jasthi Veeraiah Chowdary VC Shamim Thorakkal T

Data in brief 20180322

This data depicts the clinical evaluation of collagen membrane in oral mucosal defects due to oral submucous fibrosis and leukoplakia. This data comprised of 10 patients in the age group of 20-60 (3 male and 2 female patients with grade III and grade IV oral submucous fibrosis and 5 male patients with oral leukoplakia with a size of 3-5 cm in diameter). The parameters such as pain, swelling, allergy, biodegradability of collagen membrane, degree of re-epithelisation, degree of contracture, mouth ...[more]

PMID: 29900214

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Novel epigenetically dysregulated genes in Oral Submucous Fibrosis

Project description:DNA methylation data of normal buccal mucosa and Oral Submucous Fibrosis (OSF) afflicted mucosa.

2021-07-24 | GSE156669 | GEO

PTMA, a new identified autoantigen for oral submucous fibrosis, regulates oral submucous fibroblast proliferation and extracellular matrix.

Project description:Oral submucous fibrosis (OSF) is a chronic, insidious disease. The presence of autoantibodies in sera of OSF patients is the most characteristic and direct evidence of OSF being an autoimmune disease. To identify the specific autoantigens which could contribute to antibody production, the Human Proteome Microarrays composed of 19000 full-length unique proteins were employed. 45 proteins correlated with OSF were identified. To validate these results, we used ELISA to validate 28 OSF-associated autoantigens in extended samples. 8 autoantigens were positive in OSF serum with high frequency compared to the healthy controls. Moreover, the mRNA expression of 8 candidates was up-regulated in OSF oral submucous tissues; among them, the protein level of PTMA, the one with the highest positive frequency, was also increased. Through searching the Bioinformatics Public Database and performing the Spearman's rank correlation analysis, we observed that PTMA was positively correlated with fibrosis-related TGF?1 and SMAD4, the downstream gene of TGF?1. In TGF?1-induced fibrosis model of primary human oral submucous fibroblast, PTMA knockdown reversed TGF?1-induced fibrosis process through inhibiting the cell viability and proliferation of fibroblast, reducing the protein levels of PTMA, Collagen I, ?-SMA and MMP9 and increasing the protein levels of SMAD4. In contrast, PTMA overexpression enhanced TGF?1-induced fibrosis process. Taken together, PTMA is involved in TGF?1-induced fibrosis in the primary human submucous fibroblast by regulating the expression of ECM-related markers and the downstream genes of TGF?1. In conclusion, PTMA presents an essential autoantigen during OSF process; targeting PTMA might be a promising strategy for OSF treatment.

| S-EPMC5650380 | biostudies-other

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