Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit.

ABSTRACT: The lateral-line neuromast of the zebrafish displays a restricted, consistent pattern of innervation that facilitates the comparison of microcircuits across individuals, developmental stages, and genotypes. We used serial blockface scanning electron microscopy to determine from multiple specimens the neuromast connectome, a comprehensive set of connections between hair cells and afferent and efferent nerve fibers. This analysis delineated a complex but consistent wiring pattern with three striking characteristics: each nerve terminal is highly specific in receiving innervation from hair cells of a single directional sensitivity; the innervation is redundant; and the terminals manifest a hierarchy of dominance. Mutation of the canonical planar-cell-polarity gene vangl2, which decouples the

SUBMITTER: Dow E 

PROVIDER: S-EPMC5997450 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature