Mood instability as a predictor of clinical and functional outcomes in adolescents with bipolar I and bipolar II disorder.

ABSTRACT: BACKGROUND:Traditional assessment and treatment of bipolar disorder (BD) often overlooks an important feature of the illness, mood instability (MI). MI - the presence of intense, rapidly shifting emotional states - is associated with a number of poor prognostic outcomes. This study examined whether MI among adolescents with BD was cross-sectionally related to bipolar subtype (I vs. II) and prognostically associated with symptoms and functioning over 3 months. METHODS:Participants included 145 adolescents (mean age: 15.6 years ± 1.4) with BD I or II with a mood episode in the previous 3 months. Depression and (hypo)mania instability were computed using the root mean square successive difference (rMSSD) score, reflecting both the size and temporal order of changes in weekly depression and (h

SUBMITTER: O'Donnell LA 

PROVIDER: S-EPMC5997484 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature