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Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3?years.

ABSTRACT: BACKGROUND:Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood. METHODS:We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003-2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16?±?3?weeks gestation and in child serum at 1-3?years. Thyroid hormones were measured in serum at 3?years. We used multiple informant models to investigate associations between prenatal and early-life PBDE exposures and thyroid hormone levels at age 3?years. RESULTS:Prenatal PBDEs were associated with decreased thyroid stimulating hormone (TSH) levels at age 3?years. A 10-fold increase in prenatal ?PBDEs (BDE-28, -47, -99, -100, and -153) was associated with a 27.6% decrease (95% CI -40.8%, -11.3%) in TSH. A ten-fold increase in prenatal ?PBDEs was associated with a 0.25?pg/mL (0.07, 0.43) increase in free triiodothyronine (FT3). Child sex modified associations between prenatal PBDEs and thyroid hormones, with significant decrements in TSH among females and decreased free T4 (FT4) in males. Prenatal ?PBDEs were not associated with TT4, FT4, or total T3. CONCLUSIONS:These findings suggest an inverse relationship between prenatal ?PBDEs and TSH at 3?years. Associations may be sexually dimorphic, with an inverse relationship between prenatal BDE-47 and -99 and TSH in females and null associations among males.

SUBMITTER: Vuong AM

PROVIDER: S-EPMC5997562 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years.

Vuong Ann M AM Braun Joseph M JM Webster Glenys M GM Thomas Zoeller R R Hoofnagle Andrew N AN Sjödin Andreas A Yolton Kimberly K Lanphear Bruce P BP Chen Aimin A

Environment international 20180519

<h4>Background</h4>Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood.<h4>Methods</h4>We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003-2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16 ± 3 weeks gestation and in child serum at 1-3 years. Thyroid hormones were ...[more]

PMID: 29787984

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Project description:BackgroundExperimental studies in rodents suggest that polybrominated diphenyl ethers (PBDEs) and poly- and perfluoroalkyl substances (PFAS) may contribute to depressive symptoms. Few studies have examined the impact of these chemicals on depression in adults.ObjectiveTo examine the associations between serum PBDE and PFAS concentrations during pregnancy and repeated measures of depressive symptoms in women assessed from pregnancy to 8 years postpartum.MethodsThis study was based on 377 women from the Health Outcomes and Measures of the Environment Study, a birth cohort in Cincinnati, OH (USA). PBDEs (BDE-28, -47, -99, -100, -153, and ∑PBDEs) and PFAS (perfluorooctanoate [PFOA], perfluorooctane sulfonate [PFOS], perfluorohexane sulfonate [PFHxS], perfluorononanoate [PFNA]) were quantified in maternal serum at 16 ± 3 weeks gestation. Depressive symptoms were measured using the Beck Depression Inventory-II (BDI-II) at ~20 weeks gestation and up to seven times during postpartum visits (4 weeks, 1, 2, 3, 4, 5, and 8 years). We used linear mixed models to estimate covariate-adjusted associations between chemical concentrations and repeated measures of BDI-II. Multinomial logistic regression models were used to estimate the relative risk ratios of having a medium or high depression trajectory.ResultsWe found that a 10-fold increase in BDE-28 at 16 ± 3 weeks gestation was associated with significantly increased BDI-II scores (β = 2.5 points, 95% confidence interval [CI] 0.8, 4.2) from pregnancy to 8 years postpartum. Significant positive associations were also observed with BDE-47, -100, -153, and ∑PBDEs. A 10-fold increase in ∑PBDEs was associated with a 4.6-fold increased risk (95% CI 1.8, 11.8) of a high trajectory for BDI-II compared to a low trajectory. We observed no significant associations between PFAS and BDI-II scores.ConclusionPBDEs during pregnancy were associated with more depressive symptoms among women in this cohort.

Project description:California children's exposures to polybrominated diphenyl ether flame retardants (PBDEs) are among the highest measured worldwide. We previously reported associations for prenatal and childhood PBDE exposures with decrements in attention, processing speed, fine motor coordination, and cognition in children at ages 5 and 7 years. Here, we investigate associations of PBDEs with attention and executive function at ages 9 to 12 years in the expanded CHAMACOS cohort.We measured PBDEs in prenatal and child age 9 year serum samples for families enrolled in the study since pregnancy ("CHAM1", N=321). In a subsequent cohort for which families were enrolled at child age 9 ("CHAM2", N=301), we measured PBDEs in maternal and child samples collected at child age 9, and used predictive modeling to estimate prenatal exposure levels. We examined associations of measured and estimated PBDE concentrations on children's attention and executive functioning at ages 9, 10½, and 12 years.Geometric means for prenatal and childhood ?PBDE levels (sum of PBDE-47, -99, -100, -153) for the expanded CHAMACOS cohort were 26.3 and 63.2 ng/g lipid, respectively, and did not differ significantly between CHAM1 and CHAM2 families. We found consistent associations of prenatal exposure to PBDEs with poorer attention and executive function, measured with parent report and direct neuropsychological testing of the child. For example, using GEE models of repeated outcome measures at ages 9 and 12, a 10-fold increase in prenatal ?PBDE was associated with poorer response consistency on the Conners' Continuous Performance Test II (?=2.9; 95% CI: 0.9, 4.8) and poorer working memory on the Behavioral Rating Inventory of Executive Function (?=2.5; 95% CI: 0.5, 4.4). Child age 9 ?PBDE levels were associated with poorer parent-reported attention and executive function for girls but not boys.Our results suggest that the prefrontal cortex may be a potential target for PBDE exposure and add to a growing literature showing that these ubiquitous toxicants may adversely affect neurodevelopment.

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Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3?years.

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Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years.

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Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3?years.

Publications

Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years.

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OmicsDI is part of the ELIXIR infrastructure

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Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years.