Ontology highlight
ABSTRACT:
SUBMITTER: Reddy JA
PROVIDER: S-EPMC5997627 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20180612 1
EC1456 is a folate-tubulysin conjugate constructed with an all-D enantiomeric spacer/linker configuration. When tested against folate receptor (FR)-positive cells, EC1456 demonstrated dose-responsive activity with an approximate 1000-fold level of specificity. Treatment of nude mice bearing FR-positive human xenografts (as large as 800 mm<sup>3</sup>) with non-toxic doses of EC1456 led to cures in 100% of the mice. Combinations of low dose EC1456 with standard of care agents such as platins, tax ...[more]