Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-?1/BMP-2 activity.
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ABSTRACT:
SUBMITTER: Asparuhova MB
PROVIDER: S-EPMC5997631 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
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Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-β1/BMP-2 activity.
Asparuhova Maria B MB Caballé-Serrano Jordi J Buser Daniel D Chappuis Vivianne V
International journal of oral science 20180612 2
Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral (DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medium (BCM) extracted from locally harvested autologous bone chips have shown great regenerative potential in GBR. However, the underlying molecular mechanism remains largely unknown. Here, we investigated the composition of BCM and its activity on the osteogenic potential of mesenchy ...[more]
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