Ontology highlight
ABSTRACT:
SUBMITTER: Kang YBA
PROVIDER: S-EPMC5997652 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Kang Young Bok Abraham YBA Eo Jinsu J Mert Safak S Yarmush Martin L ML Usta O Berk OB
Scientific reports 20180612 1
An important number of healthy and diseased tissues shows spatial variations in their metabolic capacities across the tissue. The liver is a prime example of such heterogeneity where the gradual changes in various metabolic activities across the liver sinusoid is termed as "zonation" of the liver. Here, we introduce the Metabolic Patterning on a Chip (MPOC) platform capable of dynamically creating metabolic patterns across the length of a microchamber of liver tissue via actively enforced gradie ...[more]