A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies.
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ABSTRACT:
SUBMITTER: Valton J
PROVIDER: S-EPMC5997667 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies.
Valton Julien J Guyot Valerie V Boldajipour Bijan B Sommer Cesar C Pertel Thomas T Juillerat Alexandre A Duclert Aymeric A Sasu Barbra Johnson BJ Duchateau Philippe P Poirot Laurent L
Scientific reports 20180612 1
CAR T-cell therapies hold great promise for treating a range of malignancies but are however challenged by the complexity of their production and by the adverse events related to their activity. Here we report the development of the CubiCAR, a tri-functional CAR architecture that enables CAR T-cell detection, purification and on-demand depletion by the FDA-approved antibody Rituximab. This novel architecture has the potential to streamline the manufacturing of CAR T-cells, allow their tracking a ...[more]
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