A System of Cytokines Encapsulated in ExtraCellular Vesicles.
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ABSTRACT:
SUBMITTER: Fitzgerald W
PROVIDER: S-EPMC5997670 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
A System of Cytokines Encapsulated in ExtraCellular Vesicles.
Fitzgerald Wendy W Freeman Michael L ML Lederman Michael M MM Vasilieva Elena E Romero Roberto R Margolis Leonid L
Scientific reports 20180612 1
Cytokines are soluble factors that mediate cell-cell communications in multicellular organisms. Recently, another system of cell-cell communication was discovered, which is mediated by extracellular vesicles (EVs). Here, we demonstrate that these two systems are not strictly separated, as many cytokines in vitro, ex vivo, and in vivo are released in EV-encapsulated forms and are capable of eliciting biological effects upon contact with sensitive cells. Association with EVs is not necessarily a p ...[more]
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