Ontology highlight
ABSTRACT:
SUBMITTER: Dho SH
PROVIDER: S-EPMC5997699 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20180612 1
Decay-accelerating factor (CD55 or DAF) inhibits complement-dependent cytotoxicity. We determined that CD55 is overexpressed in 76.47% of human non-small cell lung cancer tissue specimens. We therefore developed a lutetium-177-labeled chimeric monoclonal antibody against CD55. CD55-specific single-chain variable fragment (scFv) was selected from a naïve chicken scFv phage-display library, converted to IgG, and radiolabeled with lutetium-177 to generate a <sup>177</sup>Lu-anti-CD55 antibody. We t ...[more]