Ontology highlight
ABSTRACT:
SUBMITTER: Susa T
PROVIDER: S-EPMC5998076 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Susa Takao T Iizuka Masayoshi M Okinaga Hiroko H Tamamori-Adachi Mimi M Okazaki Tomoki T
Scientific reports 20180613 1
Recently, the antiproliferative action of 1,25(OH)<sub>2</sub>D<sub>3</sub> (1,25D3), an active metabolite of vitamin D<sub>3</sub>, in the management of prostate cancer has been argued rigorously. In this study, we found that at a physiological concentration, 25(OH)D<sub>3</sub> (25D3), the precursor of 1,25D3 and an inactive form of vitamin D because of its much weaker binding activity to the vitamin D receptor (VDR) compared with 1,25D3, had a gene expression profile similar to that of 1,25D3 ...[more]