Unknown

Dataset Information

0

Cytoprotective Roles of a Novel Compound, MHY-1684, against Hyperglycemia-Induced Oxidative Stress and Mitochondrial Dysfunction in Human Cardiac Progenitor Cells.


ABSTRACT: Diabetic cardiomyopathy (DCM) is tightly linked to heart disorders and dysfunction or death of the cardiomyocytes including resident cardiac progenitor cells (CPCs) in diabetic patients. In order to restore loss of function of resident or transplanted CPCs, much research has focused on novel therapeutic strategies including the discovery of novel function-modulating factors such as reactive oxygen species (ROS) scavengers. Here, we developed and defined a novel antioxidant, MHY-1684, for enhancing the angiogenic potential of CPCs against ROS-related DCM. Short-term treatment with MHY-1684 restored ROS-induced CPC cell death. Importantly, MHY-1684 decreased hyperglycemia-induced mitochondrial ROS generation and attenuated hyperglycemia-induced mitochondrial fragmentation. We observed that the activation process of both Drp1 (phosphorylation at the site of Ser616) and Fis-1 is drastically attenuated when exposed to high concentrations of D-glucose with MHY-1684. Interestingly, phosphorylation of Drp1 at the site of Ser637, which is an inhibitory signal for mitochondrial fusion, is restored by MHY-1684 treatment, suggesting that this antioxidant may affect the activation and inhibition of mitochondrial dynamics-related signaling and mitochondrial function in response to ROS stress. In conclusion, our finding of the novel compound, MHY-1684, as an ROS scavenger, might provide an effective therapeutic strategy for CPC-based therapy against diabetic cardiomyopathy.

SUBMITTER: Jang WB 

PROVIDER: S-EPMC5998189 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

altmetric image

Publications

Cytoprotective Roles of a Novel Compound, MHY-1684, against Hyperglycemia-Induced Oxidative Stress and Mitochondrial Dysfunction in Human Cardiac Progenitor Cells.

Jang Woong Bi WB   Park Ji Hye JH   Ji Seung Taek ST   Lee Na Kyung NK   Kim Da Yeon DY   Kim Yeon Ju YJ   Jung Seok Yun SY   Kang Songhwa S   Lamichane Shreekrishna S   Lamichane Babita Dahal BD   Ha Jongseong J   Yun Jisoo J   Moon Hyung Ryong HR   Baek Sang Hong SH   Chung Hae Young HY   Kwon Sang-Mo SM  

Oxidative medicine and cellular longevity 20180530


Diabetic cardiomyopathy (DCM) is tightly linked to heart disorders and dysfunction or death of the cardiomyocytes including resident cardiac progenitor cells (CPCs) in diabetic patients. In order to restore loss of function of resident or transplanted CPCs, much research has focused on novel therapeutic strategies including the discovery of novel function-modulating factors such as reactive oxygen species (ROS) scavengers. Here, we developed and defined a novel antioxidant, MHY-1684, for enhanci  ...[more]

Similar Datasets

| S-EPMC7010601 | biostudies-literature
| S-EPMC9821627 | biostudies-literature
| S-EPMC5880051 | biostudies-literature
| S-EPMC7023463 | biostudies-literature
| S-EPMC8904649 | biostudies-literature
| S-EPMC5063328 | biostudies-literature
| S-EPMC7608121 | biostudies-literature
| S-EPMC6588544 | biostudies-literature
| S-EPMC4788433 | biostudies-literature
| S-EPMC4889180 | biostudies-other