Ontology highlight
ABSTRACT:
SUBMITTER: Tan J
PROVIDER: S-EPMC5998191 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Tan Jiaqi J Zhao Lei L Wang Gaoxiang G Li Tongjuan T Li Dan D Xu Qian Q Chen Xing X Shang Zhen Z Wang Jue J Zhou Jianfeng J
BioMed research international 20180530
The 11q23 of the mixed lineage leukemia 1 (<i>MLL1</i>) gene plays a crucial role in early embryonic development and hematopoiesis. The <i>MLL-AF9</i> fusion gene, resulting from chromosomal translocation, often leads to acute myeloid leukemia with poor prognosis. Here, we generated a zebrafish model expressing the human <i>MLL-AF9</i> fusion gene. Microinjection of human <i>MLL-AF9</i> mRNA into zebrafish embryos resulted in enhanced hematopoiesis and the activation of downstream genes such as ...[more]