Ontology highlight
ABSTRACT:
SUBMITTER: Dragovic SM
PROVIDER: S-EPMC5998332 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Dragovic Srdjan M SM Agunbiade Tolulope A TA Freudzon Marianna M Yang Jing J Hastings Andrew K AK Schleicher Tyler R TR Zhou Xia X Craft Sam S Chuang Yu-Min YM Gonzalez Floricel F Li Youquan Y Hrebikova Gabriela G Tripathi Abhai A Mlambo Godfree G Almeras Lionel L Ploss Alexander A Dimopoulos George G Fikrig Erol E
Cell host & microbe 20180401 4
Plasmodium infection begins with the bite of an anopheline mosquito, when sporozoites along with saliva are injected into a vertebrate host. The role of the host responses to mosquito saliva components in malaria remains unclear. We observed that antisera against Anopheles gambiae salivary glands partially protected mice from mosquito-borne Plasmodium infection. Specifically, antibodies to A. gambiae TRIO (AgTRIO), a mosquito salivary gland antigen, contributed to the protection. Mice administer ...[more]