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Modulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pulsed electromagnetic fields.


ABSTRACT: BACKGROUND:Non-depolarizing magnetic fields, like low frequency-pulsed electromagnetic fields (LF-PEMFs) have shown the ability to modulate living structures, principally by influencing synaptic activity and ion channels on cellular membranes. Recently, the CTU Mega 20 device was presented as a molecular accelerator, using energy up to 200 J and providing high-power (2 Tesla) pulsating fields with a water-repulsive (diamagnetic) action and tissue biostimulation. We tested the hypothesis that LF-PEMFs could modulate long-term corticospinal excitability in healthy brains by applying CTU Mega 20®. Ten healthy subjects without known neurological and/or psychiatric diseases entered the study. A randomized double-blind sham-controlled crossover design was employed, recording TMS parameters (amplitude variation of the motor evoked potential as index of cortical excitability perturbations of the motor system) before (pre) and after (post +?0, +?15, +?30 min) a single CTU Mega 20 session on the corresponding primary right-hand motor area, using a real (magnetic field?=?2 Tesla; intensity?=?90 J; impulse frequency?=?7 Hz; duration?=?15 min) or sham device. A two-way repeated measures ANOVA with TIME (pre, post +?0, +?15, +?30 min) and TREATMENT (real vs. sham stimulation) as within-subjects factor was applied. RESULTS:A significant TIME?×?TREATMENT interaction was found (p?

SUBMITTER: Premi E 

PROVIDER: S-EPMC5998451 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Modulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pulsed electromagnetic fields.

Premi Enrico E   Benussi Alberto A   La Gatta Antonio A   Visconti Stefano S   Costa Angelo A   Gilberti Nicola N   Cantoni Valentina V   Padovani Alessandro A   Borroni Barbara B   Magoni Mauro M  

BMC neuroscience 20180613 1


<h4>Background</h4>Non-depolarizing magnetic fields, like low frequency-pulsed electromagnetic fields (LF-PEMFs) have shown the ability to modulate living structures, principally by influencing synaptic activity and ion channels on cellular membranes. Recently, the CTU Mega 20 device was presented as a molecular accelerator, using energy up to 200 J and providing high-power (2 Tesla) pulsating fields with a water-repulsive (diamagnetic) action and tissue biostimulation. We tested the hypothesis  ...[more]

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