Ontology highlight
ABSTRACT:
SUBMITTER: Sances S
PROVIDER: S-EPMC5998748 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Stem cell reports 20180322 4
Human stem cell-derived models of development and neurodegenerative diseases are challenged by cellular immaturity in vitro. Microengineered organ-on-chip (or Organ-Chip) systems are designed to emulate microvolume cytoarchitecture and enable co-culture of distinct cell types. Brain microvascular endothelial cells (BMECs) share common signaling pathways with neurons early in development, but their contribution to human neuronal maturation is largely unknown. To study this interaction and influen ...[more]