Ontology highlight
ABSTRACT:
SUBMITTER: Leclerc JL
PROVIDER: S-EPMC5999006 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Leclerc Jenna L JL Santiago-Moreno Juan J Dang Alex A Lampert Andrew S AS Cruz Pedro E PE Rosario Awilda M AM Golde Todd E TE Doré Sylvain S
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20161119 6
Following intracerebral hemorrhage (ICH), extracellular heme precipitates secondary brain injury, which results in irreversible brain damage and enduring neurological deficits. Hemopexin (Hpx) is an endogenous protein responsible for scavenging heme, thereby modulating its intrinsic proxidant/proinflammatory properties. Although Hpx is present in the brain, the endogenous levels are insufficient to combat the massive heme overload following ICH. We hypothesized that increasing brain Hpx levels w ...[more]