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[18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne-azide cycloaddition.


ABSTRACT: A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [18F]oxadibenzocyclooctyne ([18F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts.

SUBMITTER: Boudjemeline M 

PROVIDER: S-EPMC5999037 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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[<sup>18</sup>F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne-azide cycloaddition.

Boudjemeline Mehdi M   McNitt Christopher D CD   Singleton Thomas A TA   Popik Vladimir V VV   Kostikov Alexey P AP  

Organic & biomolecular chemistry 20180101 3


A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [<sup>18</sup>F]oxadibenzocyclooctyne ([<sup>18</sup>F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts. ...[more]

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