Unknown

Dataset Information

0

[18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne-azide cycloaddition.

ABSTRACT: A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [18F]oxadibenzocyclooctyne ([18F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts.

SUBMITTER: Boudjemeline M 

PROVIDER: S-EPMC5999037 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

[<sup>18</sup>F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne-azide cycloaddition.

Boudjemeline Mehdi M   McNitt Christopher D CD   Singleton Thomas A TA   Popik Vladimir V VV   Kostikov Alexey P AP  

Organic & biomolecular chemistry 20180101 3

A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [<sup>18</sup>F]oxadibenzocyclooctyne ([<sup>18</sup>F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts. ...[more]

Similar Datasets

Unknown Artificial Membrane Fusion Triggered by Strain-Promoted Alkyne-Azide Cycloaddition.
| S-EPMC5990007 | biostudies-literature
Unknown Comparative analysis of Cu (I)-catalyzed alkyne-azide cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) in O-GlcNAc proteomics.
| S-EPMC5967854 | biostudies-literature
Unknown TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide-alkyne cycloaddition reactions.
| S-EPMC8163418 | biostudies-literature
Unknown A general method for artificial metalloenzyme formation through strain-promoted azide-alkyne cycloaddition.
| S-EPMC3996923 | biostudies-literature
Unknown A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence.
| S-EPMC3993870 | biostudies-other
Unknown Application of strain-promoted azide-alkyne cycloaddition and tetrazine ligation to targeted Fc-drug conjugates.
| S-EPMC3474869 | biostudies-literature
Unknown Facile Quenching and Spatial Patterning of Cylooctynes via Strain-Promoted Alkyne-Azide Cycloaddition of Inorganic Azides.
| S-EPMC5991799 | biostudies-literature
Unknown Electrochemically protected copper(I)-catalyzed azide-alkyne cycloaddition.
| S-EPMC3574790 | biostudies-literature
Unknown Strain-Promoted Azide-Alkyne Cycloaddition-Based PSMA-Targeting Ligands for Multimodal Intraoperative Tumor Detection of Prostate Cancer.
| S-EPMC8778659 | biostudies-literature
Unknown Chelation-assisted, copper(II)-acetate-accelerated azide-alkyne cycloaddition.
| S-EPMC2945441 | biostudies-literature