Ontology highlight
ABSTRACT:
SUBMITTER: Boudjemeline M
PROVIDER: S-EPMC5999037 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Boudjemeline Mehdi M McNitt Christopher D CD Singleton Thomas A TA Popik Vladimir V VV Kostikov Alexey P AP
Organic & biomolecular chemistry 20180101 3
A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [<sup>18</sup>F]oxadibenzocyclooctyne ([<sup>18</sup>F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts. ...[more]