Ontology highlight
ABSTRACT:
SUBMITTER: East-Seletsky A
PROVIDER: S-EPMC5999320 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
East-Seletsky Alexandra A O'Connell Mitchell R MR Burstein David D Knott Gavin J GJ Doudna Jennifer A JA
Molecular cell 20170501 3
CRISPR adaptive immunity pathways protect prokaryotic cells against foreign nucleic acids using CRISPR RNA (crRNA)-guided nucleases. In type VI-A CRISPR-Cas systems, the signature protein Cas13a (formerly C2c2) contains two separate ribonuclease activities that catalyze crRNA maturation and ssRNA degradation. The Cas13a protein family occurs across different bacterial phyla and varies widely in both protein sequence and corresponding crRNA sequence conservation. Although grouped phylogenetically ...[more]