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Data on environmentally relevant level of aflatoxin B₁-induced human dendritic cells' functional alteration.

ABSTRACT: We assessed the effects of naturally occurring levels of AFB₁ on the expression of key immune molecules and function of human monocyte-derived dendritic cells (MDDCs) by cell culture, RT-qPCR, and flow cytometry. Data here revealed that an environmentally relevant level of AFB₁ led to remarkably weakened key functional capacity of DCs, up-regulation of key transcripts and DCs apoptosis, down-regulation of key phagocytic element, CD64, and creation of pseudolicensing direction of DCs. Flow cytometry data confirmed a damage towards DCs, i.e., increased apoptosis. The detailed data and their mechanistic effects and the outcome are available in this research article (Mehrzad et al., 2018) [1]. The impaired phagocytosis capacity with triggered pseudolicensing direction of MDDCs caused by AFB₁ and dysregulation of the key functional genes could provide a mechanistic explanation for the observed in vivo immunotoxicity associated with this mycotoxin.

SUBMITTER: Mehrzad J

PROVIDER: S-EPMC5999520 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Data on environmentally relevant level of aflatoxin B1-induced human dendritic cells' functional alteration.

Mehrzad Jalil J Bahari Abbas A Bassami Mohammad Reza MR Mahmoudi Mahmoud M Dehghani Hesam H

Data in brief 20180430

We assessed the effects of naturally occurring levels of AFB1 on the expression of key immune molecules and function of human monocyte-derived dendritic cells (MDDCs) by cell culture, RT-qPCR, and flow cytometry. Data here revealed that an environmentally relevant level of AFB1 led to remarkably weakened key functional capacity of DCs, up-regulation of key transcripts and DCs apoptosis, down-regulation of key phagocytic element, CD64, and creation of pseudolicensing directi ...[more]

PMID: 29904659

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Data on environmentally relevant level of aflatoxin B₁-induced human dendritic cells' functional alteration.

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Data on environmentally relevant level of aflatoxin B<sub>1</sub>-induced human dendritic cells' functional alteration.

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