Ontology highlight
ABSTRACT:
SUBMITTER: Brendel M
PROVIDER: S-EPMC5999706 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Brendel Matthias M Yousefi Behrooz H BH Blume Tanja T Herz Michael M Focke Carola C Deussing Maximilian M Peters Finn F Lindner Simon S von Ungern-Sternberg Barbara B Drzezga Alexander A Bartenstein Peter P Haass Christian C Okamura Nobuyuki N Herms Jochen J Yakushev Igor I Rominger Axel A
Frontiers in aging neuroscience 20180607
Positron-emission-tomography (PET) imaging of tau pathology has facilitated development of anti-tau therapies. While members of the arylquinoline and pyridoindole families have been the most frequently used tau radioligands so far, analyses of their comparative performance <i>in vivo</i> are scantly documented. Here, we conducted a head-to-head PET comparison of the arylquinoline <sup>18</sup>FT807 and the pyridoindole <sup>18</sup>FTHK5117 PET in a mouse model of tau pathology. PET recordings w ...[more]