Ontology highlight
ABSTRACT:
SUBMITTER: Goralski JL
PROVIDER: S-EPMC6000726 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Goralski Jennifer L JL Wu Dan D Thelin William R WR Boucher Richard C RC Button Brian B
The European respiratory journal 20180517 5
Inhaled hypertonic saline (HS) is an effective therapy for muco-obstructive lung diseases. However, the mechanism of action and principles pertinent to HS administration remain unclear.An <i>in vitro</i> system aerosolised HS to epithelial cells at rates comparable to <i>in vivo</i> conditions. Airway surface liquid (ASL) volume and cell height responses were measured by confocal microscopy under normal and hyperconcentrated mucus states.Aerosolised HS produced a rapid increase in ASL height and ...[more]