Ontology highlight
ABSTRACT:
SUBMITTER: Chong TT
PROVIDER: S-EPMC6001457 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Journal of neuropsychology 20170405 2
Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction c ...[more]