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Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism.

ABSTRACT: Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained.

SUBMITTER: Chong TT

PROVIDER: S-EPMC6001457 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism.

Chong Trevor T-J TT Bonnelle Valerie V Veromann Kai-Riin KR Juurmaa Julius J Taba Pille P Plant Olivia O Husain Masud M

Journal of neuropsychology 20170405 2

Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction c ...[more]

PMID: 28378511

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