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ABSTRACT: Scope
In this study, we aim to determine the effects of resveratrol (RSV) on muscle atrophy in streptozocin-induced diabetic mice and to explore mitochondrial quality control (MQC) as a possible mechanism.Methods and results
The experimental mice were fed either a control diet or an identical diet containing 0.04% RSV for 8 weeks. Examinations were subsequently carried out, including the effects of RSV on muscle atrophy and muscle function, as well as on the signaling pathways related to protein degradation and MQC processes. The results show that RSV supplementation improves muscle atrophy and muscle function, attenuates the increase in ubiquitin and muscle RING-finger protein-1 (MuRF-1), and simultaneously attenuates LC3-II and cleaved caspase-3 in the skeletal muscle of diabetic mice. Moreover, RSV treatment of diabetic mice results in an increase in mitochondrial biogenesis and inhibition of the activation of mitophagy in skeletal muscle. RSV also protects skeletal muscle against excess mitochondrial fusion and fission in the diabetic mice.Conclusion
The results suggest that RSV ameliorates diabetes-induced skeletal muscle atrophy by modulating MQC.
SUBMITTER: Wang D
PROVIDER: S-EPMC6001753 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Wang Dongtao D Sun Huili H Song Gaofeng G Yang Yajun Y Zou Xiaohu X Han Pengxun P Li Shunmin S
Molecular nutrition & food research 20180423 9
<h4>Scope</h4>In this study, we aim to determine the effects of resveratrol (RSV) on muscle atrophy in streptozocin-induced diabetic mice and to explore mitochondrial quality control (MQC) as a possible mechanism.<h4>Methods and results</h4>The experimental mice were fed either a control diet or an identical diet containing 0.04% RSV for 8 weeks. Examinations were subsequently carried out, including the effects of RSV on muscle atrophy and muscle function, as well as on the signaling pathways re ...[more]