Ontology highlight
ABSTRACT:
SUBMITTER: Omardien S
PROVIDER: S-EPMC6002552 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Omardien Soraya S Ter Beek Alexander A Vischer Norbert N Montijn Roy R Schuren Frank F Brul Stanley S
Scientific reports 20180614 1
An empirical approach was taken to screen a novel synthetic compound library designed to be active against Gram-positive bacteria. We obtained five compounds that were active against spores from the model organism Bacillus subtilis and the food-borne pathogen Bacillus cereus during our population based experiments. Using single cell live imaging we were able to observe effects of the compounds on spore germination and outgrowth. Difference in sensitivity to the compounds could be observed betwee ...[more]