Ontology highlight
ABSTRACT:
SUBMITTER: Zhu D
PROVIDER: S-EPMC6002773 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Zhu Dan D Osuka Satoru S Zhang Zhaobin Z Reichert Zachery R ZR Yang Liquan L Kanemura Yonehiro Y Jiang Ying Y You Shuo S Zhang Hanwen H Devi Narra S NS Bhattacharya Debanjan D Takano Shingo S Gillespie G Yancey GY Macdonald Tobey T Tan Chalet C Nishikawa Ryo R Nelson William G WG Olson Jeffrey J JJ Van Meir Erwin G EG
Cancer cell 20180601 6
Adhesion G protein-coupled receptors (ADGRs) encompass 33 human transmembrane proteins with long N termini involved in cell-cell and cell-matrix interactions. We show the ADGRB1 gene, which encodes Brain-specific angiogenesis inhibitor 1 (BAI1), is epigenetically silenced in medulloblastomas (MBs) through a methyl-CpG binding protein MBD2-dependent mechanism. Knockout of Adgrb1 in mice augments proliferation of cerebellar granule neuron precursors, and leads to accelerated tumor growth in the Pt ...[more]