Ontology highlight
ABSTRACT:
SUBMITTER: Stavrinides AK
PROVIDER: S-EPMC6003104 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Stavrinides Anna K AK Tatsis Evangelos C EC Dang Thu-Thuy TT Caputi Lorenzo L Stevenson Clare E M CEM Lawson David M DM Schneider Bernd B O'Connor Sarah E SE
Chembiochem : a European journal of chemical biology 20180322 9
Plant monoterpene indole alkaloids, a large class of natural products, derive from the biosynthetic intermediate strictosidine aglycone. Strictosidine aglycone, which can exist as a variety of isomers, can be reduced to form numerous different structures. We have discovered a short-chain alcohol dehydrogenase (SDR) from plant producers of monoterpene indole alkaloids (Catharanthus roseus and Rauvolfia serpentina) that reduce strictosidine aglycone and produce an alkaloid that does not correspond ...[more]